DNA Ligase I Polyclonal Antibody, 100ul NGS Oligos Misregulation of this gene has

Misregulation of this gene has been implicated in tumorigenesis

|disease:Defects in CHEK2 are associated with Li-Fraumeni syndrome 2 (LFS2)

that are found in the amino terminal globular domain of all the alpha chains

The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase

Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats

DNA Ligase I Polyclonal Antibody, 100ul NGS Oligos Misregulation of this gene hasLIG1 encodes a member of the ATP dependent DNA ligase protein family. DNA ligase 1 functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA damaging agents. Disruption of LIG1 may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.