Flk-1/VEGFR2(Phospho Tyr1175) Polyclonal Antibody, 100ul Sampling Tubes Sclerostin (SOST) is a secreted

Sclerostin (SOST) is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists

The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma)

the encoded protein is acidic

and other polypeptides

Multiple alternatively spliced variants| encoding the same protein| have been identified

Flk-1/VEGFR2(Phospho Tyr1175) Polyclonal Antibody, 100ul Sampling Tubes Sclerostin (SOST) is a secretedVascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple