EDEM2 Polyclonal Antibody, 100ul DNA Synthesis Mutations in this gene may

Mutations in this gene may be associated with type 2 diabetes in human patients

The 26S proteosome complex is required for ubiquitin-dependent protein degradation

Isoforms include a full-length transmembrane receptor isoform and shortened

Several related pseudogenes have also been identified

ITGA2 encodes the alpha subunit of a transmembrane receptor for collagens and related proteins

EDEM2 Polyclonal Antibody, 100ul DNA Synthesis Mutations in this gene mayIn the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins.