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CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer This protein is an osteoblast-secreted

SKU: 9363673635

4.1
SEK162.00 SEK211.00

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CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer This protein is an osteoblast-secretedCortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F actin and Arp2 3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin

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Description

This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption

An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714)

and can bind the class III Arf ARF6 without immediate GAP activity

MAP2K6 encodes a member of the dual specificity protein kinase family

a helical hinge region involved in oligomerization

CD63 Polyclonal Antibody, 50ul[BT-AP02139] Microplate Mixer This protein is an osteoblast-secretedCortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F actin and Arp2 3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin

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