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The next stage should also adhere to the treatment principles of the previous stage

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Reductions in HbA 1c and body weight from baseline to week 26 in the overall PIONEER 12 population were greater than those observed at week 26 in the PIONEER 3 trial, which assessed oral semaglutide 3 mg, 7 mg and 14 mg vs sitagliptin 100 mg in a global population across 78 weeks [18]

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33,34 A phase 2 clinical study (NCT04313634) using senolytics (D + Q) to treat bone loss in postmenopausal women showed that patients with higher senescent cell burden had a more significant response to D + Q, manifested as a 34% increase in bone formation and an 11% decrease in bone resorption

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