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No adjustment period is needed since the active ingredient is identical

The results of in vitro studies, preclinical and clinical trial data, pharmacokinetic profile, dosing regimen, side effects, and toxicities of tirzepatide are reviewed to account for the potency, efficacy, and safety of the newly approved drug

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Patients with certain GIPR variants may experience more pronounced appetite suppression, slower gastric emptying, or differential response timing when switching dual-receptor mechanisms