EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 size:10 mg solid CAS Number: 1355324-14-9

CAS Number: 1355324-14-9

gastric (NUGC-3)

AC-55541 was well absorbed when administered intraperitoneally to rats

BG45 alone and in combination with bortezomib triggers significant tumor growth inhibition in vivo in a murine xenograft model of human MM

(2010) Neuropharmacology

EPZ015666 (GSK3235025) - PRMT5 Inhibitor. CAS# 1616391-65-1 size:10 mg solid CAS Number: 1355324-14-9EPZ015666, also known as GSK3235025, CAS No. 1616391 65 1, is a potent and selective and orally active PRMT5 inhibitor with a half maximal inhibitory concentration (IC50) of 22 nM and broad selectivity against a panel of other histone methyltransferases. Treatment of MCL cell lines with EPZ015666 led to inhibition of SmD3 methylation and cell death, with IC50 values in the nanomolar range. Oral dosing with EPZ015666 demonstrated dose dependent