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Taken together, the observations in patients by MRS studies indeed offer in vivo evidences supporting the presence of glutamatergic, redox and mitochondrial dysfunction in schizophrenia, despite many confounding factors involved such as MR methodologies, disease stage, region specificity, heterogeneity in patient cohorts and medication effects

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Last but not least, the exact mechanisms of butyrate regulation need to be found out

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Further research demonstrated that melatonin enhances recognition memory accuracy for objects encoded under stress in healthy young men, indicating its role in central nervous system processing during stress and its potential to modulate memory consolidation [222]