K-7174 dihydrochloride estin (ML246) CFTR Inhibitor II inhibits SLC26A9-mediated

CFTR Inhibitor II inhibits SLC26A9-mediated Cl- currents

Biliary excretion clearance of Fexofenadine (17 ml/min/kg) accounts for almost 60% of the total body clearance (30 ml/min/kg) in mice

Formula: C30H30Cl2N4O4

21-dimethoxy-6

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCC1=CC=CS1)[C@@H]1CC2=CC=CC(O)=C2CC1

K-7174 dihydrochloride estin (ML246) CFTR Inhibitor II inhibits SLC26A9-mediatedK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product