GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 17(9):2997-3004

17(9):2997-3004

Su-11274 inhibits HGF-dependent phosphorylation of Met as well as HGF-dependent cell proliferation and motility with an IC50 of 1-1

We monitored the effect of GNF-2 with AKIs on the proliferation and clonigenicity of the different Ba/F3 cells

Smiles: NC1=CC(=CC=C1)S(=O)(=O)N1CCCN(CC1)S(=O)(=O)C1=CC2OCCOC=2C=C1

CAS Number: 587871-26-9

GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 17(9):2997-3004GDC 0068, CAS No. 1001264 89 6, is a highly potent, selective, and orally available pan Akt inhibitor, targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. It has >100 fold selectivity over a broad panel of 230 kinases, except PRKG1 and PRKG1 with IC50 of 98 nM and 69 nM. GDC 0068 can effectively block Akt signaling and induce cell cycle arrest in human cancer cell lines in vitro, and exhibit significant efficacy in PTEN and