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Patients frequently experience spontaneous pain and heightened tenderness in affected areas, even with minimal pressure.19 This increased perception of pain often described as a constant, throbbing sensation is thought to be linked to local inflammatory processes and possible micro-neuropathic changes within the subcutaneous tissue, leading to dysregulation of local-regional sensory nerve fibers.12 Edema and microvascular abnormalities Non-pitting edema is another common manifestation, particularly as the disease progresses, which can be primarily due to an underlying chronic venous disease

At 15 mg, the same premature injection could produce severe GI distress

The mechanism behind this heart rate increase is not fully established but may involve changes in autonomic nervous system activity or other physiological adaptations

Abbreviation: GI, gastrointestinal

Before administration, patients should remove the pen from refrigeration and allow it to reach room temperature for approximately 30 minutes, as injecting cold medication may increase discomfort