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Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 Catalog No.:M60005-10S 501919-59-1

Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 Catalog No.:M60005-10S 501919-59-1

Name: Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 Catalog No.:M60005-10S 501919-59-1
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SKU: 29775776351
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Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 Catalog No.:M60005-10S 501919-59-1Wnt C59, CAS No. 1243243 89 1, is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It prevents palmitylation of Wnt proteins by Porcupine (a membrane bound O acyltransferase), thereby blocking Wnt protein secretion and activity. Wnt C59 displayed good bioavailability as once daily oral administration and blocked progression of mammary tumors in MMTV WNT1 transgenic mice model while

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Description

501919-59-1

2013 Aug 21

Discovery of potent

1/BR (BR) subclones

Design and optimization of selective protein kinase C θ (PKCθ) inhibitors for the treatment of autoimmune diseases

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