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In multivariate regression analyses heart failure (OR 6,472 [95% CI 4,066-10,302], p 140, atrial fibrillation, and cigarette use predicted WMH with an AUC of 0.83 (95% CI, 0.75-0.90) in the development cohort (N = 142, 62.212.4 years, 54% male, 38% non-white race) and 0.85 (95% CI, 0.77-0.92) in the validation cohort (N = 126, 65.916.3 years, 52% female, 34% non-white race)

Risk of bias assessment Four authors independently assessed the risk of bias (RoB) using version 2 of the Cochrane RoB tool for randomized trials (RoB 2) within the Review Manager (RevMan) computer program, version 7.2.0 (Cochrane Collaboration, London, UK) [20,21]

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