Amlexanox - CAS# 68302-57-8 Size:2 mg solid KU-60019 at 3 μM significantly

KU-60019 at 3 μM significantly inhibits migration and invasion of human glioma U87 cells by >70% and ~60%

Smiles: O=C1CC2=C(NC3=CC=C(Br)C=C32)C2=CC=CC=C2N1

BMS-983970 is a pan-Notch inhibitor

Blockade is seen with TG100-115 doses as low as 0

KW-2449 mediates cytotoxicity thru inhibition of FLT3/ITD

Amlexanox - CAS# 68302-57-8 Size:2 mg solid KU-60019 at 3 μM significantlyAmlexanox, also known as AA 673 and CHX 3673, is an anti inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor.