TIC10 Catalog No.:M8469-10 Formula: C16H12O5

Formula: C16H12O5

is a novel potent and selective inhibitor of Ces3 and Ces1f with IC50 ~0

RU-SKI 43 was used at 10-20 µM final concentration in vitro and in cellular assays

which is associated with IM resistance

CAS Number: 819812-04-9

TIC10 Catalog No.:M8469-10 Formula: C16H12O5ONC 201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53 independent manner and crosses the blood brain barrier. TIC10 induces a sustained up regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal regulated kinase (ERK), leading to the translocation