Taltobulin - CAS# 228266-40-8 Size:Solid 10 mg Functional characterization of the novel
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Taltobulin - CAS# 228266-40-8 Size:Solid 10 mg Functional characterization of the novelTaltobulin, also known as HTI 286 and SPA 110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport based resistance to taxanes. HTI 286 was a potent inhibitor of proliferation (mean IC50 = 2. 5 2. 1 nm in 18 human tumor cell lines) and had substantially less interaction with multidrug resistance protein (P glycoprotein) than currently used antimicrotubule agents, including
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