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The motor alterations depend on a reduced level of AMPc, with reduced reflex gastro-colic, increased segmenting activity, or even colonic inertia, that is, few or no peristaltic waves

doi: 10.2337/diabetes.50.8.1714

(DOC 29 kb) Supplementary Methods (download DOC This document provides additional information of the methods used in this study

When gastrointestinal transit time increases, the window for drug absorption widens unpredictably

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In a cross-sectional study on 109 children with PWS aged 218 years (50 with obesity and 59 without obesity), and 96 controls with simple obesity matched for age, gender and BMI, it was shown that children with PWS without obesity showed significantly lower frequency of hypertension (12%) than subjects with PWS and obesity (32%), and controls with simple obesity (35%), suggesting the crucial role of obesity rather than the syndrome per se in the absence of excessive weight [37]