TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 size:2mg solid Destabilization of both β-catenin and

Destabilization of both β-catenin and Ras via targeting axin is a potential therapeutic strategy for treatment of CRC and other type cancers activated Wnt/β-catenin and Ras pathways

CAS Number: 1410880-22-6

a potent inhibitor of the epidermal growth factor receptor

2(5):611-24

1001264-89-6

TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 size:2mg solid Destabilization of both β-catenin andTH 302, CAS No. 918633 87 1, is a highly potent and selective hypoxia activated pro drug targeting hypoxic regions of solid tumors with an IC50 of 19 nM. It is stable to liver microsomes. However, under hypoxic conditions, it is selectively and irreversibly converted to its active phosphoramidate based, DNA crosslinking, bis alkylator. TH 302 inhibits H460 cells and HT29 cells with IC90 of 0. 1 M and 0. 2 M, respectively. It shows much enhanced