TGR5 Receptor Agonist 273 NIK SMI1 inhibits BAFF signaling

NIK SMI1 inhibits BAFF signaling and reduces splenic marginal zone B cells in vivo

61 583 PMID: 28692295

This sensitization of tumor cell lines with AKT-IN-VIII is not limited to LnCaP cells as similar apoptosis induction is observed in HT29

53(4):1509-18

Formula: C16H12ClNO

TGR5 Receptor Agonist 273 NIK SMI1 inhibits BAFF signalingTGR5 receptor agonist, a potent TGR5 (GPCR19) agonist, showed improved potency in the U2 OS cell assay (pEC50 = 6. 8) and in melanophore cells (pEC50 = 7. 5). Product information CAS Number: 1197300 24 5 Molecular Weight: 361. 22 Formula: C18H14Cl2N2O2 Synonym: CCDC MDK00245 Chemical Name: 3 (2 chlorophenyl) N (4 chlorophenyl) N,5 dimethyl 4 isoxazolecarboxamide Smiles: CC1ON=C(C=1C(=O)N(C)C1C=CC(Cl)=CC=1)C1=CC=CC=C1Cl InChiKey: IGRCWJPBLWGNPX