WP1130 (Degrasyn) - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 856243-80-6 426 Stoelben S

Stoelben S

Probes1_000316

Oral dosing of GNF7156 in diabetic mice induces β-cell proliferation

colon weight per unit length in the control group is more than twice that in the normal group

Pre-treatment with 1 μM inhibits migration to a greater extent in the non-gradient assay than in the gradient assay

WP1130 (Degrasyn) - Deubiquitinylating Enzyme (DUB) Inhibitor. CAS# 856243-80-6 426 Stoelben SWP1130 (Degrasyn), CAS No. 856243 80 6, is a cell permeable, potent and selective inhibitor of the deubiquitinylating enzymes (DUBs). At 5 M it directly inhibits DUB activity of USP9x, USP5, USP14, UCH L1, and UCH37, but not UCH L3, resulting in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL 1 and p53. WP1130 suppresses Bcr Abl, JAK2 transducer (without affecting 20S proteasome) and activator of transcription