XMD8-92 Size:Solid 2 mg (2006) Nature 442(7104):823-6

(2006) Nature 442(7104):823-6

8 and 16 μM) significantly inhibits the proliferation of A2780 and SK-OV-3 cell lines in a dose- and time-dependent manner

Smiles: NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2C3=NC=C(Br)C=C3CCC3=CC(Cl)=CC(Br)=C32)CC1

Formula: C35H48N6O8

and is not effective in significantly reducing clinical signs

XMD8-92 Size:Solid 2 mg (2006) Nature 442(7104):823-6XMD8 92 is an ERK5 BMK1 inhibitor and also BRD4 inhibitor. XMD8 92 inhibits pancreatic tumor xenograft growth via a DCLK1 dependent mechanism. XMD8 92 blocks cellular BMK1 activation and significantly suppresses tumor growth in lung and cervical tumor models and is well tolerated in animals. Product information CAS Number: 1234480 50 2 Molecular Weight: 474. 55 Formula: C26H30N6O3 Chemical Name: 5 {[2 ethoxy 4 (4 hydroxypiperidin 1 yl)phenyl]amino}