Safinamide tatoside A selective and cell permeable HDAC3

selective and cell permeable HDAC3 inhibitor

Smiles: CC1(C)C=CC2=CC(CCN3C4=CC=CC=C4C4=CC=CC=C34)=CC(C=O)=C2O1

PubMed PMID: 24179414

and has been shown to improve mitochondrial function and to confer significant cellular protection in neurons under stress

InChiKey: HVXKQKFEHMGHSL-GOOCMWNKSA-N

Safinamide tatoside A selective and cell permeable HDAC3Safinamide, also known as FCE 26743 and EMD 1195686, is a drug indicated for the treatment of Parkinson's disease with multiple methods of action. Potential additional uses might be restless legs syndrome (RLS) and epilepsy. Safinamide is a reversible and selective monoamine oxidase B inhibitor, reducing degradation of dopamine, and a glutamate release inhibitor. It also inhibits dopamine reuptake. Additionally, safinamide blocks sodium and calcium