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I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 60186 Smiles: C1C=NSC=1SSC1=CC=NS1

I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 60186 Smiles: C1C=NSC=1SSC1=CC=NS1

Name: I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 60186 Smiles: C1C=NSC=1SSC1=CC=NS1
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I-BET762 (GSK525762) - BET Inhibitor. CAS# 1260907-17-2 60186 Smiles: C1C=NSC=1SSC1=CC=NS1I BET762 (GSK525762), CAS No. 1260907 17 2, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~35 nM. It suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation. It is highly selective over other bromodomain containing proteins. In vivo studies using I BET762 have demonstrated efficacy in a range of oncology and

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Description

Smiles: C1C=NSC=1SSC1=CC=NS1

7 µM concentration in beta cell proliferation assays

11(2):242-52

Pehamberger H

Formula: C22H24Cl2N2O4

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