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This so-called aerobic glycolysis or the Warburg effect provides swift ATP and, crucially, generates metabolic intermediates for biosynthetic pathways (pentose phosphate pathway for nucleotides, glycerol for lipids) necessary for cell growth, proliferation, and cytokine production [40]

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The production of -ketoglutarate supports successful decidualization through epigenetic regulation of histone modifications and energy provision (58)

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Diarrhea was reported across all dose groups but was significantly more frequent and more severe at higher doses

doi:10.1124/jpet.111.182220