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Opioid analgesics, including oxycodone and acetaminophen tablets, can prolong labor through actions which temporarily reduce the strength, duration, and frequency of uterine contractions

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It means that as a standalone oral therapy at the tested doses, it did not produce the magnitude of weight loss that pharmaceutical companies require for commercial viability

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Dosage and form Higher doses or advanced delivery methods (like effervescent tablets) tend to give stronger results, so their absence may be felt more