AM095 olide CAS Number: 881188-51-8

CAS Number: 881188-51-8

Expert Opin Investig Drugs

It abrogated DNA damaged checkpoints induced by gemcitabine

n/a (try to use IDH-C35 for in vivo studies)

InChi: InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H

AM095 olide CAS Number: 881188-51-8AM095 is a potent LPA1 receptor antagonist because it inhibited GTPS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0. 98 and 0. 73 M, respectively, and exhibited no LPA1 agonism. Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at least six G protein coupled receptors designated LPA1 6. LPA type 1 receptor (LPA1) exhibits widespread