AZD1080 - CAS# 612487-72-6 Size:Solid 10 mg Wogonin inhibits β-catenin-mediated transcription through

Wogonin inhibits β-catenin-mediated transcription through suppressing the activity of CDK8

Brunstein E

Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM

1-8H3/t19-

InChi: InChI=1S/C20H16O4/c1-20(2)8-7-13-9-12(3-6-17(13)24-20)16-11-23-18-10-14(21)4-5-15(18)19(16)22/h3-11

AZD1080 - CAS# 612487-72-6 Size:Solid 10 mg Wogonin inhibits β-catenin-mediated transcription throughAZD 1080 is a potent and selective GSK3 inhibitor that demonstrates peripheral target engagement in Phase 1 clinical studies. AZD1080 inhibits tau phosphorylation in cells expressing human tau and in intact rat brain. Interestingly, subchronic but not acute administration with AZD1080 reverses MK 801 induced deficits, measured by long term potentiation in hippocampal slices and in a cognitive test in mice, suggesting that reversal of synaptic