PF-4708671 60072 EHop-016 is a novel potent

EHop-016 is a novel potent and selective inhibitor of RAC

also known as DGAT1-IN-3

Cheong et al (2018) A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N6-methyladenosine demethylase activity in cells

15(2):275-81

InChi: InChI=1S/C36H56O6/c1-21(2)22-12-17-36(30(40)41)19-18-34(8)23(28(22)36)10-11-25-33(7)15-14-26(42-27(37)20-31(3

PF-4708671 60072 EHop-016 is a novel potentPF 4708671 is a novel cell permeable inhibitor of S6K1. PF 4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF 4708671 prevents the S6K1 mediated phosphorylation of S6 protein in response to IGF 1 (insulin like growth factor 1), while having no effect upon the PMA induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen and stress activated kinase) kinases. Product