JNJ-40411813 mifugin Su-11274 exhibits greater than 50-fold

Su-11274 exhibits greater than 50-fold selectivity for Met versus Flk and more than 500 times selectivity versus other tyrosine kinases such as FGFR-1

also known as S-4661 and Finibax

2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen-1-one

InChi: InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H

InChiKey: QOECJCJVIMVJGX-UHFFFAOYSA-N

JNJ-40411813 mifugin Su-11274 exhibits greater than 50-foldJNJ 40411813, also known as ADX71149, is a positive allosteric modulator of the mGlu2 receptor. JNJ 40411813 acts as a PAM at the cloned mGlu2 receptor: EC50 = 147 42 nmol L in a [(35)S]GTPS binding assay with human metabotropic glutamate type 2 (hmGlu2) CHO cells and EC50 = 64 29 nmol L in a Ca(2+) mobilization assay with hmGlu2 G 16 cotransfected HEK293 cells. JNJ 40411813 displaced [(3)H]JNJ 40068782 and [(3)H]JNJ 46281222 (mGlu2 receptor PAMs),