PIK-75 hydrochloride G 149 and 100 mg/kg) dose-dependently reduces

and 100 mg/kg) dose-dependently reduces sepsis-induced mortality and lung injury in cecal ligation and puncture (CLP-)induced sepsis mice through inhibiting CLP-induced serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production

C6H6O3S/c1-31(35(2

8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

CGP60474 is also a PKC inhibitor

5-trifluorophenyl)-

PIK-75 hydrochloride G 149 and 100 mg/kg) dose-dependently reducesPIK 75 was developed as part of a PI 3 kinase drug discovery program. PIK75 attenuates insulin stimulation of Akt PKB in a range of cell types at 100 nM. The compound has been reported to block growth of a range of cell lines with an IC50 value in the region of 50 nM. In vivo studies have shown that PIK 75, administered at 50 mg kg, inhibited the growth of HeLa cell xenografts in mice models. Product information CAS Number: 372196 77 5 Molecular