MCU i4 0073 which promotes differentiation of hESCs/iPSCs

which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation

o) exhibits good oral bioavailability (77%) and the maximum exposure level in plasma (Cmax) is 24 μM

Burslem GM

However in the intact RBL-I cell prostaglandin synthetase (IC50 of 3

and has weaker activity against monoamine oxidase proteins MAO-A and MAO-B with IC50 ~0

MCU i4 0073 which promotes differentiation of hESCs/iPSCsMCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex, which binds to MICU1, a regulatory protein within MCU complex. MCU i4 reduces mitochondrial Ca2+ uptake in multiple cell lines including MEFs, MDA MB,231 and HEK293T cells, and demonstrates a negative effect on mitochondrial membrane potential. In ex vivo muscle fibres, MCU i4 reduces mitochondrial Ca2+ uptake and impairs muscle cell growth. Product information CAS