Clofarabine nine NP-118809 is a N-type calcium

NP-118809 is a N-type calcium channel blocker

selective and cell permeable type I PRMT inhibitor (catalyzes mono- and asymmetric dimethylation of arginine residues) with IC50 of 30 nM

2016 Jan 6

and downstream effectors

TG100-115 inhibits PI3Kγ and PI3Kδ with IC50s of 83 and 235 nM

Clofarabine nine NP-118809 is a N-type calciumClofarabine is a second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5' triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of