GSK256066 (2,2,2-trifluoroacetic acid) rbidopa with Ki of 0

with Ki of 0

The TAM tyrosine kinase receptors Tyro3

CAS Number: 951131-15-0

UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 of 81 nM

E)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

GSK256066 (2,2,2-trifluoroacetic acid) rbidopa with Ki of 0GSK256066 is a potent and selective PDE4 inhibitor that can be given by inhalation, minimising the potential for side effects. GSK256066 demonstrated a protective effect on the EAR and LAR. GSK256066 is a slow and tight binding inhibitor of PDE4B (apparent IC(50) 3. 2 pM; steady state IC(50) <0. 5 pM), which is more potent than any previously documented compound, for example, roflumilast (IC(50) 390 pM), tofimilast (IC(50) 1. 6 nM), and cilomilast