AM966 Size:Solid 10 mg Formula: C11H6BrCl2NO3S2

Formula: C11H6BrCl2NO3S2

Fed Regist

A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes

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KW-2449 mediates cytotoxicity thru inhibition of FLT3/ITD

AM966 Size:Solid 10 mg Formula: C11H6BrCl2NO3S2AM966 is a potent, selective, and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model. In vitro, AM966 inhibited LPA stimulated intracellular calcium release from Chinese hamster ovary cells stably expressing human LPA(1) receptors and inhibited LPA induced chemotaxis of human IMR 90 lung fibroblasts expressing LPA(1) receptors. AM966 reduced lung injury, vascular leakage, inflammation and fibrosis at