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Y-39983 HCl - CAS# 173897-44-4 0217 Smiles: CN(C)C1C=CC(=CC=1)C(C1=CC(=CC=C1Cl)[N+]([O-])=O)C1C=CC(=CC=1)N(C)C

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Y-39983 HCl - CAS# 173897-44-4 0217 Smiles: CN(C)C1C=CC(=CC=1)C(C1=CC(=CC=C1Cl)[N+]([O-])=O)C1C=CC(=CC=1)N(C)CY 39983 HCl, CAS No. 173897 44 4, also known as Y 33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3. 6nM for ROCK. Y 39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y 39983 downregulates RhoA Rho associated kinase expression during its promotion of axonal regeneration. Y 39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.

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Description

Smiles: CN(C)C1C=CC(=CC=1)C(C1=CC(=CC=C1Cl)[N+]([O-])=O)C1C=CC(=CC=1)N(C)C

PubMed PMID: 24690597

108(7):1318-1327

Marsilje TH

Molecular Weight: 224

Y-39983 HCl - CAS# 173897-44-4 0217 Smiles: CN(C)C1C=CC(=CC=1)C(C1=CC(=CC=C1Cl)[N+]([O-])=O)C1C=CC(=CC=1)N(C)CY 39983 HCl, CAS No. 173897 44 4, also known as Y 33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3. 6nM for ROCK. Y 39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y 39983 downregulates RhoA Rho associated kinase expression during its promotion of axonal regeneration. Y 39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.

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