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In the case of KBP-089, a dual amylin and CTR agonist, the additivity of DACRAs and GLP-1 RA in improved insulin sensitivity and body weight reduction was demonstrated in the ratanimal model [119, 120]

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Regarding hepatosteatosis grading, larger differences were observed in the None (SMD = 0.55) and Grade 3 (SMD = 0.54) categories, whereas Grade 1 (SMD = 0.08) and Grade 2 (SMD = 0.14) were relatively balanced between groups

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Follicular cysts are usually 3-8 cm, but may become much larger

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