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AAE-581 - CAS# 354813-19-7 Catalog No.:M60434-10S Brain-penetrant LSD1 inhibitors can block

AAE-581 - CAS# 354813-19-7 Catalog No.:M60434-10S Brain-penetrant LSD1 inhibitors can block

Name: AAE-581 - CAS# 354813-19-7 Catalog No.:M60434-10S Brain-penetrant LSD1 inhibitors can block
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AAE-581 - CAS# 354813-19-7 Catalog No.:M60434-10S Brain-penetrant LSD1 inhibitors can blockBalicatib(AAE 581), CAS No. 354813 19 7, is a potent and selective inhibitor of cathepsin K; 10 100 fold more potent in cell based enzyme occupancy assays than against cathepsin B, L, and S. IC50 value: Target: cathepsin K The cathepsin K inhibitor AAE 581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage

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Description

Brain-penetrant LSD1 inhibitors can block memory consolidation

Chemical Name: 3-(3-(cyclopentylthio)-5-(((2-methyl-4'-(methylsulfonyl)-[1

1152/ajpcell

Curr Pharm Des

and extracellular signal-regulated kinase phosphorylation

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