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Cells 12 (1), 90

doi: 10.1007/s00401-017-1731-9 160 LiCDengXXieXLiuYFriedmann AngeliJPLaiL

Growth hormone and insulin-like growth factor I regulate collagen gene expression and extracellular collagen in cultures of avian skin fibroblasts

In addition to their anti-inflammatory effects, these compounds have inhibitory effects on the following pathways: inflammasome (NLRP3), Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, endothelial cell vascular cell adhesion molecule-1 (VCAM-1) or intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinases involved in remodelling and metastasis (MMP 2, MMP 9), and chronic cycloxogenase derived prostaglandins that promote angiogenesis and immunosuppression (182)