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PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S (2008) Oncogene

PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S (2008) Oncogene

Name: PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S (2008) Oncogene
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PFI-1 - BET Inhibitor. CAS# 1403764-72-6 Catalog No.:M60120-10S (2008) OncogenePFI 1, CAS No. 1403764 72 6, is a novel potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2 and BRD4 with IC50 of ~98 nM and 220 nM respectively. Co crystal structures showed that PFI 1 acts as an acetyl lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD2 and BRD4. It has an EC50 of 1. 89 M for the inhibition of IL6 production from human blood mononuclear cells

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Description

(2008) Oncogene

and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice

Rakkestad KE

Siddiqui-Jain A

Su-11274 induces G1 cell cycle arrest with cells in G1 phase increased from 42

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