Nutlin-3, (4R5S, and 4S5R) Catalog No.:M7686-10 Sinclair KD

Sinclair KD

CHR-2797 exhibits profound anti-proliferative effects against a range of cancer cell lines such as U-937

a linker and an VHL binding group

Metformin increases ATM and AMPK phosphorylation

TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1

Nutlin-3, (4R5S, and 4S5R) Catalog No.:M7686-10 Sinclair KDNutlin 3 is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin 3 activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein. Product information CAS Number: 548472 68 0 Molecular Weight: 581. 49 Formula: C30H30Cl2N4O4 Synonym: () Nutlin 3 Nutlin 3 Related CAS Number: