DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid CAS Number: 1351758-81-0

CAS Number: 1351758-81-0

It is highly selective over related enzymes such as MAO-A/B

It may represent a good lead compound for a subset of Parkinson's disease

which are osteogenic factors that regulate the maturation of osteogenic progenitor cells into more differentiated osteoblast cells

CAS Number: 847925-91-1

DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:10 mg solid CAS Number: 1351758-81-0DASA 58 (ML203), CAS No. 1203494 49 8, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. DASA 58 inhibits LPS induced Hif 1 and IL 1, as well as the expression of a range of other Hif 1 dependent