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Mol Pharmacol (2008) 74:40312

M2 macrophages exhibit angiogenic and proinvasive properties, producing growth factors, chemokines, and MMPs that stimulate tumor growth, invasion, and metastasis (93), particularly facilitating tumor cell extravasation and growth in secondary sites

Possibly, its function of pumping non-metabolized xenobiotics out of the cell and back into the intestinal lumen, may allow more opportunities for phase I activity to metabolize the xenobiotic before it is taken into circulation

Lung tissue showed mild infiltration of inflammatory cells and alveolar destruction, while micro-CT images revealed pathological changes, including high-density foci suggestive of pneumonia