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These procedures are reserved for patients with a BMI 40 kg/m 2 , or a BMI 35 kg/m 2 with obesity-related complications and patients must be refractory to other weight management intervention despite specialist input [78]

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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels