LB-100 tosylate 3]oxazino[5

3]oxazino[5

Efficacy and safety of cinepazide maleate injection in patients with acute ischemic stroke: a multicenter

7'-difluoro-3H-spiro[isobenzofuran-1

Molecular Weight: 318

2016 Jan 20:ajpcell

LB-100 tosylate 3]oxazino[5LB 100 is a protein phosphatase 2A(PP2A)inhibitor. LB 100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. LB 100 enhanced the effects of sorafenib in HCC cells only during hypoxic environments. LB 100 dramatically increased intracellular p Smad3 level, which was responsible for the effect of LB 100 as a sensitizer. LB 100 downregulated Bcl 2 expression and enhanced sorafenib