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10.2337/db05-1602 [DOI] [PubMed] [Google Scholar] 136.Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, et al

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In mouse models of Parkinson's disease, treatment with NLY01 for five months was protective against neurodegeneration

Embryofetal mortality, structural abnormalities (e.g., visceral and skeletal abnormalities), and alterations to growth were observed in the offspring of rats who were administered semaglutide during organogenesis at dosages resulting in systemic exposures lower than the maximum recommended human dosage

Modeling studies ( Diabetes Obes Metab 2025 Apr;27(4):2251-2258) do suggest that biweekly dosing can preserve approximately 70% of the weight loss effects seen with once weekly dosing