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In this experiment we provide evidence that increasing GLP1 to supraphysiological levels during a glucose challenge confers a degree of protection against acute olanzapine induced perturbations in glucose and lipid metabolism

Compared with short-acting GLP-1 RAs, which essentially reduce postprandial glucose by delaying gastric emptying, long-acting GLP-1 RAs often result in constant medication exposure and maintain relative concentrations over 24 h and/or over a week, even if the interval between parenteral therapy is a day or a week [27]

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