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The 1_localizer sequence and 1 H signal were employed for brain localization, and the 2_localizer_shim sequence was utilized for field homogenization

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Mass Spectrometry Applications Mass spectrometry enables: N-terminal truncation identification C-terminal truncation analysis Relative impurity quantification Structural confirmation of shortened variants Why Truncation Monitoring Matters These variants can potentially affect: Product potency Stability Pharmacokinetics Regulatory comparability assessments As a result, truncation products must be carefully monitored throughout biosimilar development