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According to the Wegovy Summary of Product Characteristics (SmPC), treatment should be discontinued if a patient has not lost at least 5% of their initial body weight after 12 weeks on the maintenance dose (2.4 mg once weekly)

However, other investigations have suggested that several GLP-1RAs may cross the bloodbrain barrier via passive diffusion 251 , a GLP-1R-mediated uptake mechanism 252 or adsorption transcytosis 253 , although different compounds may present with variable degrees of brain penetrance 254

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doi: 10.3899/jrheum.140021

Gather your supplies: You'll need your medication (removed from the refrigerator 15 to 30 minutes before injection to reduce discomfort - check your specific medications instructions), alcohol swabs, a syringe and needle (if using a compounded vial) or a pen needle (if using a pre-filled pen), a sharps disposal container (your pharmacy may provide one, or you can purchase one at any drugstore), and a clean paper towel or gauze pad

Mild hypoglycaemia (low blood sugar) could occur, mainly when combined with other medications like insulin or sulfonylureas